The one issue I have seen so far with VMware storage is with regards to NFS datastores; they have to be configured onto each node in the cluster individually. Since this is done manually, it can be prone to error, so I started using the following powershell commands to perform it on all the hosts in a cluster.
foreach ($ESXhost in get-cluster clustername| get-vmhost)
New-datastore –nfs –vmhost $ESXhost –name datastorename –path /export/share –nfshost servername
Simply replace the clustername, datastorename, /export/share and servername with the appropriate values and run it in the VI Toolkit Powershell extension